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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   Anti-AGO2 / EIF2C2 Antibody (clone 2E12-1C9)   

Anti-AGO2 / EIF2C2 Antibody (clone 2E12-1C9)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UKV8
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 2E12-1C9
Calculated MW 97208 Da
Dilution ELISA, IF (10 µg/ml), IHC-P (3 - 5 µg/ml), WB
Additional Information
Gene ID 27161
Alias Symbol AGO2
Other Names AGO2, Argonaute2, Argonaute 2, EIF-2C 2, EIF2C2, EIF2C 2, HAgo2, PPD, Protein slicer, Q10, PAZ Piwi domain protein, Protein argonaute-2
Target/Specificity Human EIF2C2
Reconstitution & Storage Protein A purified
PrecautionsAnti-AGO2 / EIF2C2 Antibody (clone 2E12-1C9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGO2
Synonyms EIF2C2
Function Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
Cellular Location Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8
Research Areas
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$ 450.00
Cat# ALS17714
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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