|Application ||WB, IHC-P, E|
|Calculated MW||21849 Da|
|Dilution||ELISA, IHC-P (3 - 5 µg/ml), WB (1:500 - 1:1000)|
|Other Names||CLEC2D, C-type lectin related f, CLAX, LLT-1, LLT1, OCIL, Osteoclast inhibitory lectin, Lectin-like NK cell receptor, Lectin-like transcript 1|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-CLEC2D / OCIL / LLT1 Antibody (clone 4C7) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLAX, LLT1, OCIL|
|Function||Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Cell surface Isoform 4: Endoplasmic reticulum.|
|Tissue Location||Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells|
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