|Application ||WB, IHC-P, E|
|Calculated MW||30773 Da|
|Dilution||ELISA, IHC-P (5 µg/ml), WB|
|Other Names||VDAC1, HVDAC1, Plasmalemmal porin, Porin 31HM, PORIN, PORIN-31-HL, Vdac5, VDAC, Mitochondrial porin, Porin 31HL, VDAC-1|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-VDAC1 / PORIN Antibody (clone 2A8) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).|
|Cellular Location||Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Membrane raft; Multi-pass membrane protein|
|Tissue Location||Heart, liver and skeletal muscle.|
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