Anti-ING3 Antibody (clone 2E9)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9NXR8 |
Predicted | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a,k |
Clone Names | 2E9 |
Calculated MW | 46743 Da |
Dilution | ELISA, IHC-P (5 µg/ml), WB |
Gene ID | 54556 |
---|---|
Alias Symbol | ING3 |
Other Names | ING3, p47ING3, Inhibitor of growth protein 3, MEAF4, Eaf4, p47 |
Target/Specificity | Human ING3 |
Reconstitution & Storage | Protein A purified |
Precautions | Anti-ING3 Antibody (clone 2E9) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ING3 |
---|---|
Function | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus |
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