|Application ||WB, IHC-P, E|
|Predicted||Human, Rabbit, Dog|
|Calculated MW||54393 Da|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.1 - 0.3 µg/ml)|
|Other Names||ERO1L, ERO1-like (S. cerevisiae), ERO1 (S. cerevisiae)-like, ERO1A, ERO1-alpha, ERO1-L-alpha, ERO1-like protein alpha, Oxidoreductin-1-L-alpha, ERO1-L|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-ERO1A / ERO1L Antibody (aa105-118) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum|
|Tissue Location||Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.