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Anti-IST1 Antibody

Mouse Anti Human Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P53990
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 39751 Da
Dilution ELISA, IHC-P (10 µg/ml), WB (1:1000)
Additional Information
Gene ID 9798
Alias Symbol IST1
Other Names IST1, CRS1, HIST1, IST1 homolog, KIAA0174, OLC1, Increased sodium tolerance-1, SCS, Overexpressed in lung cancer 1, TWACS3
Target/Specificity Anti-hIST1 recognizes hIST1 expression in H520 whole cell lysate.
Reconstitution & Storage Affinity purified
PrecautionsAnti-IST1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IST1
Synonyms KIAA0174
Function ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
Cellular Location Cytoplasmic vesicle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus envelope. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPG20 to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the nuclear envelope during late anaphase (PubMed:26040712)
Research Areas
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$ 395.00
Cat# ALS17730
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