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Anti-IST1 Antibody
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P53990 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 39751 Da |
| Dilution | ELISA, IHC-P (10 µg/ml), WB (1:1000) |
| Gene ID | 9798 |
|---|---|
| Alias Symbol | IST1 |
| Other Names | IST1, CRS1, HIST1, IST1 homolog, KIAA0174, OLC1, Increased sodium tolerance-1, SCS, Overexpressed in lung cancer 1, TWACS3 |
| Target/Specificity | Anti-hIST1 recognizes hIST1 expression in H520 whole cell lysate. |
| Reconstitution & Storage | Affinity purified |
| Precautions | Anti-IST1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IST1 |
|---|---|
| Synonyms | KIAA0174 |
| Function | ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129480, PubMed:19129479). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). |
| Cellular Location | Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus envelope Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# ALS17730
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