|Application ||IHC-P, E|
|Calculated MW||53924 Da|
|Dilution||ELISA (1:8000), IHC-P (3.75 µg/ml)|
|Other Names||CHN2, ARHGAP3, Beta-chimerin, BCH, Beta3-chimaerin, CHN2-3, Chimerin 2, RHOGAP3, Beta-chimaerin, Chimerin (chimaerin) 2|
|Target/Specificity||Human CHN2. This antibody is expected to recognize both reported isoforms (NP_004058.1; NP_001035025.1).|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CHN2 / Chimerin 2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.|
|Cellular Location||Membrane; Peripheral membrane protein|
|Tissue Location||Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas|
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