|Application ||WB, IHC-P, E, Neut|
|Calculated MW||48291 Da|
|Dilution||ELISA (0.5 - 2 µg/ml), IHC-P (5 µg/ml), Neut (15 - 20 µg/ml), WB (0.1 - 0.2 µg/ml)|
|Other Names||TNFRSF1B, CD120b antigen, CD120b, Etanercept, p75 TNF receptor, Soluble TNFR1B variant 1, TNFBR, Tumor necrosis factor receptor, TNF-R-II, TNF-R75, TNFR2, p75TNFR, p80 TNF-alpha receptor, TBPII, TNF-R2, TNFR80, TNF-RII, TNFR-II, TNFR1B|
|Target/Specificity||Human sTNF Receptor-II|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-TNFRSF1B / TNFR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Tumor necrosis factor-binding protein 2: Secreted|
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