|Application ||WB, IHC-P, E, Neut|
|Calculated MW||20055 Da|
|Dilution||ELISA (0.5 - 2 µg/ml), IHC-P (5 µg/ml), Neut (2.5 - 3.7 µg/ml), WB (0.1 - 0.2 µg/ml)|
|Other Names||IL1RN, Anakinra, DIRA, IL-1ra, IL-1RN, IL1F3, IL1RA, MVCD4, IL1 inhibitor, IL1RN (IL1F3), IRAP, ICIL-1RA, IL-1ra3|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-IL1RN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.|
|Cellular Location||Isoform 1: Secreted. Isoform 3: Cytoplasm.|
|Tissue Location||The intracellular form of IL1RN is predominantly expressed in epithelial cells|
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