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Anti-HDAC5 Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UQL6
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 121978 Da
Dilution IHC-P (5 µg/ml), IP (20 µg/ml), WB (0.5 - 4 µg/ml)
Additional Information
Gene ID 10014
Alias Symbol HDAC5
Other Names HDAC5, Antigen NY-CO-9, Histone deacetylase 5, NY-CO-9, HD5, KIAA0600
Target/Specificity The antibody detects ~124 kD histone deacetylase 5. It does not cross-react with other HDAC proteins including HDAC1, 2, 3, 4, 6, 7, and 8.
Reconstitution & Storage Affinity purified
PrecautionsAnti-HDAC5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC5
Synonyms KIAA0600
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1
Tissue Location Ubiquitous.
Research Areas
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$ 450.00
Cat# ALS17752
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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