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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-Carom / FCHSD2 Antibody
Anti-Carom / FCHSD2 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O94868 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 84276 Da |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 9873 |
|---|---|
| Alias Symbol | FCHSD2 |
| Other Names | FCHSD2, Carom, FCH and double SH3 domains 2, NWK, KIAA0769, Nervous wreck homolog, SH3 multiple domains 3, SH3 multiple domains protein 3, SH3MD3 |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-Carom / FCHSD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FCHSD2 |
|---|---|
| Synonyms | KIAA0769, SH3MD3 |
| Function | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to- late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3USJ8}. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3USJ8}. Note=Partially localized at clathrin-coated pits at the cell membrane (PubMed:30249660). Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits (PubMed:29887380) Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions (PubMed:14627983). |
| Tissue Location | Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. |
Research Areas
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Discontinued
Cat# ALS17762
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