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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-RCOR1 / COREST Antibody (aa109-293)
Anti-RCOR1 / COREST Antibody (aa109-293)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, ICC, IP |
|---|---|
| Primary Accession | Q9UKL0 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 53327 Da |
| Dilution | ICC, IHC-P (10 µg/ml), IP, WB |
| Gene ID | 23186 |
|---|---|
| Alias Symbol | RCOR1 |
| Other Names | RCOR1, COREST, Protein CoREST, REST corepressor 1, RCOR, KIAA0071, REST corepressor |
| Target/Specificity | Recognizes human CoREST, Mr ~66kD. Species cross-reactivity: Mouse and rat. |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-RCOR1 / COREST Antibody (aa109-293) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RCOR1 |
|---|---|
| Synonyms | KIAA0071, RCOR |
| Function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453}. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner |
| Tissue Location | Ubiquitously expressed. |
Research Areas
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