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Anti-RCOR1 / COREST Antibody (clone S72-8)

Mouse Anti Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UKL0
Predicted Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names S72-8
Calculated MW 53028 Da
Dilution ICC, IHC-P (5 µg/ml), IP, WB
Additional Information
Gene ID 23186
Alias Symbol RCOR1
Other Names RCOR1, COREST, Protein CoREST, REST corepressor 1, RCOR, KIAA0071, REST corepressor
Target/Specificity Detects ~66-80kDa (dependingon gel system used).
Reconstitution & Storage Protein G purified
PrecautionsAnti-RCOR1 / COREST Antibody (clone S72-8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCOR1
Synonyms KIAA0071, RCOR
Function Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453} Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner
Tissue Location Ubiquitously expressed.
Research Areas
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$ 395.00
Cat# ALS17776
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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