|Calculated MW||37408 Da|
|Other Names||CD68, CD68 antigen, gp110, SCARD1, CD68 molecule, LAMP4, Macrophage antigen CD68, Macrosialin|
|Precautions||Anti-CD68 Antibody (clone PG-M1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.|
|Cellular Location||Isoform Short: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites|
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