|Application ||WB, IHC-P, IF, IP|
|Calculated MW||43123 Da|
|Dilution||IF, IHC-P (10 µg/ml), IP (0.5 - 1 µg/ml), WB (0.5 - 1 µg/ml)|
|Other Names||MFGE8, Breast epithelial antigen BA46, EDIL1, HP47, Lactadherin, Medin, MFGM, Milk fat globule-EGF factor 8, HsT19888, OAcGD3S, SPAG10, Sperm associated antigen 10, MFG-E8, SED1, Sperm surface protein hP47, BA46, HMFG|
|Reconstitution & Storage||Protein G purified|
|Precautions||Anti-MFGE8 /Lactadherin Antibody (clone EDM45) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.|
|Cellular Location||Membrane; Peripheral membrane protein Secreted|
|Tissue Location||Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas|
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