Anti-ESYT2 / E-Syt2 Antibody (clone 1E10)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | A0FGR8 |
Predicted | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a,k |
Clone Names | 1E10 |
Calculated MW | 102357 Da |
Dilution | ELISA, IHC-P (10 µg/ml), WB |
Gene ID | 57488 |
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Alias Symbol | ESYT2 |
Other Names | ESYT2, CHR2SYT, Chr2 synaptotagmin, FAM62B, KIAA1228, E-Syt2, Extended synaptotagmin-2 |
Target/Specificity | Human ESYT2 |
Reconstitution & Storage | Protein A purified |
Precautions | Anti-ESYT2 / E-Syt2 Antibody (clone 1E10) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ESYT2 (HGNC:22211) |
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Synonyms | FAM62B, KIAA1228 |
Function | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). |
Cellular Location | Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437) |
Tissue Location | Widely expressed with high level in cerebellum. |
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