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Anti-ESYT2 / E-Syt2 Antibody (clone 1E10)

Mouse Anti Human Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession A0FGR8
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a,k
Clone Names 1E10
Calculated MW 102357 Da
Dilution ELISA, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 57488
Alias Symbol ESYT2
Other Names ESYT2, CHR2SYT, Chr2 synaptotagmin, FAM62B, KIAA1228, E-Syt2, Extended synaptotagmin-2
Target/Specificity Human ESYT2
Reconstitution & Storage Protein A purified
PrecautionsAnti-ESYT2 / E-Syt2 Antibody (clone 1E10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESYT2 (HGNC:22211)
Synonyms FAM62B, KIAA1228
Function Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890).
Cellular Location Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437)
Tissue Location Widely expressed with high level in cerebellum.
Research Areas
Citations (0)
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Discontinued
Cat# ALS17808
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