|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat, Rabbit, Hamster, Monkey|
|Calculated MW||40668 Da|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.5 - 2 µg/ml)|
|Other Names||PPP2R4, PP2A phosphatase activator, PP2A subunit B isoform PR53, PTPA, PP2A, PP2A, subunit B, PR53 isoform, PR53|
|Target/Specificity||Human PPP2R4. This antibody is expected to recognize all reported isoforms (NP_821068.1; NP_066954.2; NP_821070.1). Reported variants NP_066954.2 and NP_821067.1 represent identical protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-PPP2R4 Antibody (aa347-358) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed.|
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