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Anti-PSMB8 / LMP7 Antibody (aa263-276)

Goat Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28062
Predicted Human
Host Goat
Clonality Polyclonal
Calculated MW 30354 Da
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.01 - 0.03 µg/ml)
Additional Information
Gene ID 5696
Alias Symbol PSMB8
Other Names PSMB8, D6S216, ALDD, Low molecular mass protein 7, LMP7, JMP, Proteasome subunit beta 5i, Proteasome subunit beta type-8, PSMB5i, Macropain subunit C13, Y2, NKJO, Protease component C13, Proteasome component C13, Proteasome subunit beta-5i, Proteasom ...
Target/Specificity Human PSMB8. This antibody is expected to recognize both reported isoforms (NP_004150.1; NP_683720.2).
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-PSMB8 / LMP7 Antibody (aa263-276) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMB8
Synonyms LMP7, PSMB5i, RING10, Y2
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.
Cellular Location Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus
Research Areas
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$ 395.00
Cat# ALS17813
(40 western blots)
Availability: 5 days
Bulk Size
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