Anti-TIPRL / TIP Antibody (aa257-270)
Goat Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O75663 |
Predicted | Human, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 31444 Da |
Dilution | ELISA (1:16000), IHC-P (3.75 µg/ml), WB (1 - 3 µg/ml) |
Gene ID | 261726 |
---|---|
Alias Symbol | TIPRL |
Other Names | TIPRL, Type 2A-interacting protein, DJ69E11.3, RP1-69E11.1, TIP, TIP41, TIP41-like protein |
Target/Specificity | Human TIPRL. This antibody is expected to recognize isoform 1 (NP_690866.1). |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-TIPRL / TIP Antibody (aa257-270) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TIPRL |
---|---|
Function | May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine- protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. |
Cellular Location | Cytoplasm. |
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