|Application ||WB, IHC-P, E|
|Calculated MW||31444 Da|
|Dilution||ELISA (1:16000), IHC-P (3.75 µg/ml), WB (1 - 3 µg/ml)|
|Other Names||TIPRL, Type 2A-interacting protein, DJ69E11.3, RP1-69E11.1, TIP, TIP41, TIP41-like protein|
|Target/Specificity||Human TIPRL. This antibody is expected to recognize isoform 1 (NP_690866.1).|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-TIPRL / TIP Antibody (aa257-270) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.|
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