|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||12179 Da|
|Dilution||IHC-P (5 µg/ml), WB (0.5 - 4 µg/ml)|
|Other Names||TYROBP, DNAX-activation protein 12, DAP12, PLOSL, KARAP, KAR-associated protein, PLO-SL|
|Target/Specificity||Recognizes mouse DAP-12. Species cross-reactivity: human, rat.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-DAP12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.|
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