|Application ||WB, IHC-P, E|
|Calculated MW||17419 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||AGTRAP, ATRAP|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-AGTRAP / ATRAP Antibody (clone 1G2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles|
|Tissue Location||Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.|
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