|Application ||WB, IHC-P|
|Calculated MW||39336 Da|
|Dilution||IHC-P (5 µg/ml), WB|
|Other Names||C5AR1, C5A, C5a-R, C5a ligand, C5a receptor, CD88, C5a anaphylatoxin receptor, C5AR, C5R1, CD88 antigen|
|Target/Specificity||The antibody recognizes human complement C5a and its dimer form. Reactivity to other species has not been tested|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-C5AR1 / CD88 / C5a Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles|
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