|Application ||WB, IHC-F, IF, E|
|Calculated MW||24428 Da|
|Dilution||ELISA, IF (10 µg/ml), IHC-Fr (1:50), WB|
|Other Names||PSMD10, 26s proteasome subunit 10, Ankyrin repeat protein, DJ889N15.2, Gankyrin, p28, p28(GANK)|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-PSMD10 / Gankyrin Antibody (clone 4B5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).|
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