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> home > Products > Primary Antibodies > Signal Transduction > Anti-PSMD10 / Gankyrin Antibody (clone 4B5)
Anti-PSMD10 / Gankyrin Antibody (clone 4B5)
Mouse Anti Human Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-F, IF, E |
|---|---|
| Primary Accession | O75832 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | 4B5 |
| Calculated MW | 24428 Da |
| Dilution | ELISA, IF (10 µg/ml), IHC-Fr (1:50), WB |
| Gene ID | 5716 |
|---|---|
| Alias Symbol | PSMD10 |
| Other Names | PSMD10, 26s proteasome subunit 10, Ankyrin repeat protein, DJ889N15.2, Gankyrin, p28, p28(GANK) |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-PSMD10 / Gankyrin Antibody (clone 4B5) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PSMD10 |
|---|---|
| Function | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level). |
Research Areas
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