|Application ||WB, IHC-F, IF, E|
|Calculated MW||24428 Da|
|Dilution||ELISA, IF (10 µg/ml), IHC-Fr (1:50), WB|
|Other Names||PSMD10, 26s proteasome subunit 10, Ankyrin repeat protein, DJ889N15.2, Gankyrin, p28, p28(GANK)|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-PSMD10 / Gankyrin Antibody (clone 4B5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.