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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-PSMD10 / Gankyrin Antibody (clone 4B5)   

Anti-PSMD10 / Gankyrin Antibody (clone 4B5)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75832
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 4B5
Calculated MW 24428 Da
Dilution ELISA, IF (10 µg/ml), IHC-Fr (1:50), WB
Additional Information
Gene ID 5716
Alias Symbol PSMD10
Other Names PSMD10, 26s proteasome subunit 10, Ankyrin repeat protein, DJ889N15.2, Gankyrin, p28, p28(GANK)
Reconstitution & Storage Protein A purified
PrecautionsAnti-PSMD10 / Gankyrin Antibody (clone 4B5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMD10
Function Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Cellular Location Cytoplasm. Nucleus
Tissue Location Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).
Research Areas
Citations (0)

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$ 450.00
Cat# ALS17850
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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