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> home > Products > Primary Antibodies > Signal Transduction > Anti-VHL / Von Hippel Lindau Antibody (aa167-179)
Anti-VHL / Von Hippel Lindau Antibody (aa167-179)
Goat Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P40337 |
| Predicted | Human, Mouse, Rat, Rabbit, Monkey, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 24153 Da |
| Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (0.01 - 0.03 µg/ml) |
| Gene ID | 7428 |
|---|---|
| Alias Symbol | VHL |
| Other Names | VHL, Elongin binding protein, HRCA1, RCA1, VHL1, Von Hippel-Lindau syndrome, Protein G7, PVHL |
| Target/Specificity | Human VHL. This antibody is expected to recognise both reported isoforms (NP_000542.1 and NP_937799.1). |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-VHL / Von Hippel Lindau Antibody (aa167-179) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VHL |
|---|---|
| Function | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). |
| Cellular Location | [Isoform 1]: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated (PubMed:9751722) Colocalizes with ADRB2 at the cell membrane (PubMed:19584355) |
| Tissue Location | Expressed in the adult and fetal brain and kidney. |
Research Areas
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