|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat, Rabbit, Monkey, Dog|
|Calculated MW||24153 Da|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (0.01 - 0.03 µg/ml)|
|Other Names||VHL, Elongin binding protein, HRCA1, RCA1, VHL1, Von Hippel-Lindau syndrome, Protein G7, PVHL|
|Target/Specificity||Human VHL. This antibody is expected to recognise both reported isoforms (NP_000542.1 and NP_937799.1).|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-VHL / Von Hippel Lindau Antibody (aa167-179) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.|
|Cellular Location||Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated Colocalizes with ADRB2 at the cell membrane|
|Tissue Location||Expressed in the adult and fetal brain and kidney|
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