|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rabbit, Hamster, Pig, Bovine, Horse, Guinea Pig, Dog|
|Calculated MW||69366 Da|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.2 - 0.5 µg/ml)|
|Other Names||MEX3C, RNF194, RING finger protein 194, RNA-binding protein MEX3C, BM-013, Mex-3 homolog C (C. elegans), MEX-3C, RKHD2|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-MEX3C Antibody (aa541-554) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation|
|Tissue Location||Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine|
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