|Application ||WB, IHC-P|
|Calculated MW||195626 Da|
|Dilution||IHC-P (1:200), WB (1:500 - 1:1000)|
|Other Names||CEP152, Centrosomal protein of 152 kDa, Centrosomal protein 152kDa, KIAA0912, MCPH9, MCPH4, SCKL5, Asterless|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CEP152 Antibody (Arg877) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with CEP63 in a discrete ring around the proximal end of the parental centriole At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. Localizes to the deuterosome|
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