|Application ||WB, IHC-P, IF, E|
|Calculated MW||18648 Da|
|Dilution||ELISA, IF (10 µg/ml), IHC-P (10 µg/ml), WB|
|Other Names||CIRBP, A18 hnRNP, A18HNRNP, CIRP|
|Target/Specificity||Human CIRP / CIRBP|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-CIRP / CIRBP Antibody (clone 1C9) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.|
|Cellular Location||Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).|
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