|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat, Chicken, Bovine, Dog|
|Calculated MW||155344 Da|
|Dilution||ELISA (1:100000 - 1:400000), IHC-P (5 µg/ml), WB (1:2000 - 1:20000)|
|Other Names||POGZ, KIAA0461, SUHW5, ZNF280E, Zinc finger protein 280E, ZNF635m, Zinc finger protein 635, ZNF635|
|Target/Specificity||This antibody is known to react with mouse Pogz protein. A BLAST analysis was used to suggest cross-reactivity with Pogz from human, dog, short-tailed opossum, cattle, rat, chimpanzee, macaque, olive baboon, and chicken sources based on 100% homology ...|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-POGZ Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0461, SUHW5, ZNF280E, ZNF635|
|Function||Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.|
|Cellular Location||Nucleus. Chromosome. Cytoplasm. Note=According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).|
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