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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-BLIMP1 / PRDM1 Antibody (C-Terminus)
Anti-BLIMP1 / PRDM1 Antibody (C-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP |
|---|---|
| Primary Accession | O75626 |
| Predicted | Human, Mouse, Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 91771 Da |
| Dilution | ELISA (1:65000 - 1:80000), IHC-P (5 µg/ml), IP (5 - 10 µg/ml), WB (1:1000) |
| Gene ID | 639 |
|---|---|
| Alias Symbol | PRDM1 |
| Other Names | PRDM1, BLIMP-1, BLIMP1, PRDI-binding factor-1, PRDI-BF1, PR domain-containing protein 1, PRDI-binding factor 1 |
| Target/Specificity | This antibody is predicted to react with BLIMP1 and its isoforms from human, mouse, rat and other sources based on a 100% homology with the immunizing sequence. This antibody may also recognize other proteins that show high homology/identity with the ... |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-BLIMP1 / PRDM1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRDM1 |
|---|---|
| Synonyms | BLIMP1 |
| Function | Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue- resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta- interferon gene (PubMed:1851123). Drives the maturation of B- lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). |
| Cellular Location | Nucleus. Cytoplasm |
Research Areas
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