|Application ||WB, IHC-P, E|
|Calculated MW||83055 Da|
|Dilution||ELISA (1:10000), IHC-P (1:100), WB (1:500 - 1:2000)|
|Other Names||SUZ12, ChET 9 protein, Joined to JAZF1 protein, CHET9, JJAZ1, KIAA0160, Polycomb protein SUZ12|
|Reconstitution & Storage||Ascites|
|Precautions||Anti-SUZ12 Antibody (clone 3D10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CHET9, JJAZ1, KIAA0160|
|Function||Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.|
|Tissue Location||Overexpressed in breast and colon cancer.|
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