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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-SUZ12 Antibody (clone 3D10)
Anti-SUZ12 Antibody (clone 3D10)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q15022 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 3D10 |
| Calculated MW | 83055 Da |
| Dilution | ELISA (1:10000), IHC-P (1:100), WB (1:500 - 1:2000) |
| Gene ID | 23512 |
|---|---|
| Alias Symbol | SUZ12 |
| Other Names | SUZ12, ChET 9 protein, Joined to JAZF1 protein, CHET9, JJAZ1, KIAA0160, Polycomb protein SUZ12 |
| Target/Specificity | Human SUZ12 |
| Reconstitution & Storage | Ascites |
| Precautions | Anti-SUZ12 Antibody (clone 3D10) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SUZ12 |
|---|---|
| Synonyms | CHET9, JJAZ1, KIAA0160 |
| Function | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). |
| Cellular Location | Nucleus Note=Localizes to chromatin as part of the PRC2 complex |
| Tissue Location | Overexpressed in breast and colon cancer. |
Research Areas
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