|Calculated MW||44562 Da|
|Dilution||IHC-P (7.5 µg/ml)|
|Other Names||FKBP8, 38 kDa FKBP, 38 kDa FK506-binding protein, FKBP-8, FK506-binding protein 8, FKBP38, HFKBP38, FKBP-38, Rotamase, FK506 binding protein 8, 38kDa, FK506-binding protein 8 (38kD), FKBPr38, PPIase FKBP8|
|Target/Specificity||Human FKBP38 / FKBP8|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-FKBP38 / FKBP8 Antibody (aa42-276) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.|
|Cellular Location||Isoform 1: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side|
|Tissue Location||Widely expressed. Highest levels seen in the brain. Highly abundant in the retina|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.