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Anti-FKBP38 / FKBP8 Antibody (aa42-276)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q14318
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 44562 Da
Dilution IHC-P (7.5 µg/ml)
Additional Information
Gene ID 23770
Alias Symbol FKBP8
Other Names FKBP8, 38 kDa FKBP, 38 kDa FK506-binding protein, FKBP-8, FK506-binding protein 8, FKBP38, HFKBP38, FKBP-38, Rotamase, FK506 binding protein 8, 38kDa, FK506-binding protein 8 (38kD), FKBPr38, PPIase FKBP8
Target/Specificity Human FKBP38 / FKBP8
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-FKBP38 / FKBP8 Antibody (aa42-276) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FKBP8
Synonyms FKBP38
Function Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297).
Cellular Location Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side [Isoform 3]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side
Tissue Location Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.
Research Areas
Citations (0)
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Discontinued
Cat# ALS17895
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