|Calculated MW||44562 Da|
|Dilution||IHC-P (7.5 µg/ml)|
|Other Names||FKBP8, 38 kDa FKBP, 38 kDa FK506-binding protein, FKBP-8, FK506-binding protein 8, FKBP38, HFKBP38, FKBP-38, Rotamase, FK506 binding protein 8, 38kDa, FK506-binding protein 8 (38kD), FKBPr38, PPIase FKBP8|
|Target/Specificity||Human FKBP38 / FKBP8|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-FKBP38 / FKBP8 Antibody (aa42-276) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.|
|Cellular Location||Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side Isoform 3: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side|
|Tissue Location||Widely expressed. Highest levels seen in the brain. Highly abundant in the retina|
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