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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-GOK / STIM1 Antibody (N-Terminus)
Anti-GOK / STIM1 Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q13586 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77423 Da |
| Dilution | ELISA (1:10000), IHC-P (5 µg/ml), WB (1 µg/ml) |
| Gene ID | 6786 |
|---|---|
| Alias Symbol | STIM1 |
| Other Names | STIM1, D11S4896E, Stromal interaction molecule 1, GOK, STIM1L |
| Target/Specificity | BLAST analysis suggests cross-reactivity with rat, bovine, and mouse based on 100% sequence homology. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-GOK / STIM1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STIM1 |
|---|---|
| Synonyms | GOK {ECO:0000303|PubMed:9377559} |
| Function | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as a Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release- activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Cytoplasm, cytoskeleton. Sarcoplasmic reticulum. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159) Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the cell membrane (PubMed:27185316). Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316). |
| Tissue Location | Ubiquitously expressed in various human primary cells and tumor cell lines. |
Research Areas
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