|Application ||WB, IHC-P, IP|
|Predicted||Human, Mouse, Rat, Rabbit, Monkey, Bovine, Dog|
|Calculated MW||50495 Da|
|Dilution||IHC-P (5 µg/ml), IP, WB (1:1000)|
|Other Names||TNFRSF1A, CD120a, CD120a antigen, MS5, p60, TBP1, TNF-R55, TNFAR, TNFR1, p55-R, TNF-R, TNF-R-I, TNF-R1, TNF-RI, Tnfr, TNFR-I, TNFR1-d2, TNFR60, FPF, p55, Tbpi, TNFR55|
|Target/Specificity||Identifies a band ~55kD on WB.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-TNFRSF1A / TNFR1 Antibody (aa20-43) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single- pass type I membrane protein Secreted. Note=A secreted form is produced through proteolytic processing|
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