|Application ||WB, IHC-P, IF, ICC|
|Predicted||Human, Mouse, Rat|
|Calculated MW||26152 Da|
|Dilution||ICC (1:1000), IF (1:1000), IHC-P (1:50), WB (1:10000)|
|Other Names||LGALS3, 35 kd lectin, 35 kDa lectin, CBP35, GAL3, Galactoside-binding protein, GALIG, IgE-binding protein, Laminin-binding protein, Gal-3, GALBP, MAC-2, Mac-2 antigen, L31, MAC2, CBP 35, Galactose-specific lectin 3, Galectin-3, L-31, Lectin L-29|
|Target/Specificity||Clone 5C21 is known to react with Galectin-3 from human, mouse and rat. Since Galectin-3 is highly conserved, it is likely that the antibody is effective on other species also.|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-LGALS3 / Galectin 3 Antibody (clone 52C1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface|
|Tissue Location||A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages Expressed in fetal membranes.|
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