|Application ||WB, IHC-P, E|
|Calculated MW||12806 Da|
|Dilution||ELISA (1:16000), IHC-P (5 µg/ml), WB (0.3 - 1 µg/ml)|
|Other Names||SDHAF1, LYRM8, LYR motif-containing protein 8, SDH assembly factor 1|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SDHAF1 Antibody (aa102-115) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Ubiquitously expressed.|
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