|Application ||WB, IHC-P, E|
|Predicted||Human, Hamster, Pig, Bovine, Horse, Guinea Pig, Dog|
|Calculated MW||65894 Da|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (1 - 3 µg/ml)|
|Other Names||MMP14, Membrane type-1 MMP, MT1-MMP, MT1MMP, MT-MMP, MT-MMP 1, Matrix metalloproteinase-14, MMP-14, MMP-X1, MTMMP1|
|Target/Specificity||Human MMP14 / MMP-14|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-MMP14 Antibody (aa152-163) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm|
|Tissue Location||Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors|
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