|Application ||WB, IHC-P, E|
|Calculated MW||61410 Da|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (0.1 - 0.3 µg/ml)|
|Other Names||GGT1, CD224 antigen, CD224, Ec 220.127.116.11, Glutamyl transpeptidase, GTG, Gamma-glutamyltransferase, Glutathione hydrolase 1, GLUTATHIONURIA, Gamma-glutamyl transpeptidase, Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, GGT, Leukotriene-C4 ...|
|Target/Specificity||Human GGT1 / GGT. Reported variants represent identical protein: NP_038347.2, NP_001027536.1, NP_001027537.1, NP_005256.2.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-GGT1 / GGT Antibody (aa180-193) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein|
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