|Application ||WB, IHC-P, E|
|Calculated MW||81276 Da|
|Dilution||ELISA (1:64000), IHC-P (5 µg/ml), WB (1 - 3 µg/ml)|
|Other Names||VCAM1, CD106, CD106 antigen, INCAM-100, V-CAM 1, VCAM-1|
|Target/Specificity||Human VCAM1 / VCAM-1 / CD106. This antibody is expected to recognize isoform a (NP_001069.1) and isoform c (NP_001186763.1).|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-VCAM1 / CD106 Antibody (aa349-362) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue|
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