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Anti-VCAM1 / CD106 Antibody (aa349-362)

Goat Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P19320
Predicted Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 81276 Da
Dilution ELISA (1:64000), IHC-P (5 µg/ml), WB (1 - 3 µg/ml)
Additional Information
Gene ID 7412
Alias Symbol VCAM1
Other Names VCAM1, CD106, CD106 antigen, INCAM-100, V-CAM 1, VCAM-1
Target/Specificity Human VCAM1 / VCAM-1 / CD106. This antibody is expected to recognize isoform a (NP_001069.1) and isoform c (NP_001186763.1).
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-VCAM1 / CD106 Antibody (aa349-362) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VCAM1
Function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Serves also as a quality- control checkpoint for entry into bone marrow by providing a 'don't- eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567).
Cellular Location [Vascular cell adhesion protein 1]: Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue
Research Areas
Citations (0)
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Discontinued
Cat# ALS17920
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