Anti-MPS1 / TTK Antibody (clone 3G7)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P33981 |
Predicted | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a,k |
Clone Names | 3G7 |
Calculated MW | 97072 Da |
Dilution | ELISA, IHC-P (10 µg/ml), WB |
Gene ID | 7272 |
---|---|
Alias Symbol | TTK |
Other Names | TTK, Cancer/testis antigen 96, ESK, Esk1, MPS1, MPS1L1, Protein kinase esk, PYT, TTK protein kinase, CT96, Monopolar spindle 1-like 1 |
Target/Specificity | Human MPS1 / TTK |
Reconstitution & Storage | Protein A purified |
Precautions | Anti-MPS1 / TTK Antibody (clone 3G7) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TTK |
---|---|
Synonyms | MPS1, MPS1L1 |
Function | Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). |
Tissue Location | Present in rapidly proliferating cell lines. |
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