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Anti-FGB / Fibrinogen Beta Chain Antibody (aa177-190)

Goat Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P02675
Predicted Human, Monkey, Pig, Horse
Host Goat
Clonality Polyclonal
Calculated MW 55928 Da
Dilution ELISA (1:128000), IHC-P (5 µg/ml), WB (0.01 - 0.03 µg/ml)
Additional Information
Gene ID 2244
Alias Symbol FGB
Other Names FGB, Fibrinogen, B beta polypeptide, Fibrinogen beta chain
Target/Specificity Human FGB. This antibody is expected to recognize both reported isoforms (NP_005132.2; NP_001171670.1).
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-FGB / Fibrinogen Beta Chain Antibody (aa177-190) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGB
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Cellular Location Secreted
Tissue Location Detected in blood plasma (at protein level).
Research Areas
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$ 395.00
Cat# ALS17933
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