|Application ||WB, IHC-P, E|
|Predicted||Human, Monkey, Pig, Horse|
|Calculated MW||55928 Da|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (0.01 - 0.03 µg/ml)|
|Other Names||FGB, Fibrinogen, B beta polypeptide, Fibrinogen beta chain|
|Target/Specificity||Human FGB. This antibody is expected to recognize both reported isoforms (NP_005132.2; NP_001171670.1).|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-FGB / Fibrinogen Beta Chain Antibody (aa177-190) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.|
|Tissue Location||Detected in blood plasma (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.