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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-SERPINB1 Antibody (aa65-80)
Anti-SERPINB1 Antibody (aa65-80)
Goat Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P30740 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 42742 Da |
| Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (1 - 3 µg/ml) |
| Gene ID | 1992 |
|---|---|
| Alias Symbol | SERPINB1 |
| Other Names | SERPINB1, Anti-elastase, EI, LEI, Leukocyte elastase inhibitor, Peptidase inhibitor 2, PI-2, MNEI, ELANH2, M/NEI, PI2, Serpin B1 |
| Target/Specificity | Human SERPINB1 |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-SERPINB1 Antibody (aa65-80) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERPINB1 |
|---|---|
| Synonyms | ELANH2, MNEI, PI2 |
| Function | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). |
| Cellular Location | Secreted. Cytoplasm. Cytolytic granule. Early endosome |
| Tissue Location | In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes |
Research Areas
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