|Application ||WB, IHC-P, E|
|Calculated MW||29083 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||SNAI1, DJ710H13.1, Protein sna, SNAIL, Snail 1, Snail 1, zinc finger protein, Snail homolog 1 (Drosophila), SNA, Snail 1 homolog, Protein snail homolog 1, SNAH, Snail 1 zinc finger protein, Zinc finger protein SNAI1, SLUGH2, SNAIL1|
|Target/Specificity||SNAI1 Antibody detects endogenous levels of total SNAI1 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SNAI1 / SNAIL-1 Antibody (aa215-264) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.|
|Cellular Location||Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs|
|Tissue Location||Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.|
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