|Application ||WB, IHC-P, E|
|Calculated MW||13527 Da|
|Dilution||ELISA, IHC-P (20 µg/ml), WB|
|Other Names||SNRPD2, Sm-D2, SMD2, SnRNP core protein D2|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-SNRPD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes|
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