|Application ||WB, IHC-P, E|
|Calculated MW||30375 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||CBR1, Carbonyl reductase 1, Carbonyl reductase (NADPH) 1, HCBR1, Prostaglandin 9-ketoreductase, SDR21C1, Carbonyl reductase [NADPH] 1, CBR, CRN, Prostaglandin-E(2) 9-reductase|
|Target/Specificity||CBR1 Antibody detects endogenous levels of total CBR1 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CBR / CBR1 Antibody (aa181-230) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CBR, CRN, SDR21C1|
|Function||NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.|
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