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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-AATF Antibody (clone 3C7)   

Anti-AATF Antibody (clone 3C7)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NY61
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 3C7
Calculated MW 63133 Da
Dilution ELISA, IF (10 µg/ml), IHC-P (10 µg/ml), WB
Additional Information
Gene ID 26574
Alias Symbol AATF
Other Names AATF, CHE1, DED, Rb-binding protein Che-1, CHE-1, Protein AATF
Target/Specificity Human AATF
Reconstitution & Storage Protein A purified
PrecautionsAnti-AATF Antibody (clone 3C7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CHE1, DED
Function May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Cellular Location Nucleus, nucleolus
Tissue Location Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus
Research Areas
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$ 450.00
Cat# ALS17982
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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