|Application ||WB, IHC-P, E|
|Calculated MW||16703 Da|
|Dilution||ELISA (1:100 - 1:200), IHC-P (1:100), WB (1:100 - 1:400)|
|Other Names||AIF1, AIF-1, Em:AF129756.17, G1, IRT-1, Protein G1, IBA1, IRT1|
|Target/Specificity||Rat AIF1 / IBA1|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-AIF1 / IBA1 Antibody (aa1-147) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis|
|Tissue Location||Detected in T-lymphocytes and peripheral blood mononuclear cells.|
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