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Anti-YBX1 / YB1 Antibody (clone 4F12)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P67809
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a,k
Clone Names 4F12
Calculated MW 35924 Da
Dilution ELISA, IF (20 µg/ml), IHC-P (10 µg/ml), WB
Additional Information
Gene ID 4904
Alias Symbol YBX1
Other Names YBX1, CBF-A, DBPB, CSDB, DNA-binding protein B, MDR-NF1, NSEP-1, NSEP1, Y box binding protein 1, Y-box transcription factor, Y-box-binding protein 1, YB-1, BP-8, CSDA2, EFI-A, Enhancer factor I subunit A, YB1
Target/Specificity Human YBX1 / YB1
Reconstitution & Storage Protein A purified
PrecautionsAnti-YBX1 / YB1 Antibody (clone 4F12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name YBX1
Synonyms NSEP1, YB1
Function Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.
Cellular Location Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress
Research Areas
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$ 395.00
Cat# ALS17987
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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