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Anti-ITGA7 / Integrin Alpha 7 Antibody (clone 8G2)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13683
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a,k
Clone Names 8G2
Calculated MW 128948 Da
Dilution ELISA, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 3679
Alias Symbol ITGA7
Other Names ITGA7, Alpha 7b integrin, Integrin alpha-7, Integrin alpha 7 chain, Integrin, alpha 7
Target/Specificity Human ITGA7 / Integrin Alpha 7
Reconstitution & Storage Protein A purified
PrecautionsAnti-ITGA7 / Integrin Alpha 7 Antibody (clone 8G2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA7
Function Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle
Research Areas
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$ 395.00
Cat# ALS17988
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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