|Application ||WB, IHC-P, E|
|Calculated MW||44244 Da|
|Dilution||ELISA, IHC-P (3 - 10 µg/ml), WB|
|Other Names||WTAP, HFL(2)D, KIAA0105, PNAS-132, WT1-associated protein, Female-lethal(2)D homolog|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-WTAP Antibody (clone 1B11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).|
|Cellular Location||Nucleus, nucleoplasm. Nucleus speckle|
|Tissue Location||Ubiquitously expressed.|
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