|Application ||IHC-P, IHC-F, IP, Flo|
|Calculated MW||30619 Da|
|Dilution||Flo (1:100 - 1:200), IHC-Fr, IHC-P (10 µg/ml), IP|
|Other Names||CD40, B-cell surface antigen CD40, B cell-associated molecule, B cell surface antigen CD40, CD40 antigen, CD40 type II isoform, p50, Bp50, CD40L receptor, CDW40, TNFRSF5|
|Target/Specificity||Recognizes the human CD40 cell surface antigen, a 48kD glycoprotein expressed by B lymphocytes and weakly by some monocytes. CD40 is involved in the process of B cell selection in germinal centers and is vital in T cell-B cell interactions.|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-CD40 Antibody (clone LOB7/6, Low Endotoxin) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.|
|Cellular Location||Isoform I: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||B-cells and in primary carcinomas.|
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